Holden McNeil is a New Jersey comic book writer who is roommates with his best friend and professional partner, artist Banky Edwards. Their hit comic book series, "Bluntman and Chronic," is loosely patterned after a pair of acquaintances, Jay and Silent Bob. Alyssa Jones, a lesbian and fellow comic book creator, comes into Holden’s life and quickly becomes a close friend, although Holden is powerfully attracted to her. Eventually, Alyssa realizes that she is attracted to Holden as well and they begin a physical relationship, much to the consternation of Banky, whose ire over losing his best friend to a lesbian seems to border on romantic jealousy. After he learns something about Alyssa's sexual past, however, Holden's immature response to his new knowledge destroys both his romance with Alyssa and his friendship with Banky.